Kuyucu 2004 (G+E vs P+E).
| Methods | (see Kuyucu 2004) | |
| Participants | (see Kuyucu 2004) | |
| Interventions | (see Kuyucu 2004) This glucocorticoid versus placebo comparison includes data from Group 1 (epinephrine + dexamethasone) versus Group 3 (epinephrine + placebo) |
|
| Outcomes | (see Kuyucu 2004) | |
| Funding | (see Kuyucu 2004) | |
| Notes | (see Kuyucu 2004) | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | "randomised fashion"; randomised to the first treatment, "randomised fashion independent of the first randomization" for the second treatment; no further information provided |
| Allocation concealment (selection bias) | Unclear risk | "Preparation and administration of nebulized solutions were performed by a trained emergency department nurse." |
| Blinding (performance bias and detection bias) Health care use ((re)admissions, LOS, return visits) | Unclear risk | Double‐blind; "parents and investigators remained blinded to administered medications throughout study period" |
| Blinding (performance bias and detection bias) Clinical parameters (severity scales, SpO2, respiratory and heart rate) | Unclear risk | Double‐blind; "parents and investigators remained blinded to administered medications throughout study period" |
| Blinding (performance bias and detection bias) Other outcomes (adverse events, others) | Unclear risk | Double‐blind; "parents and investigators remained blinded to administered medications throughout study period" |
| Incomplete outcome data (attrition bias) Health care use ((re)admissions, LOS, return visits) | High risk | 21 patients with missing outcome data, imbalanced between groups; no motives reported |
| Incomplete outcome data (attrition bias) Clinical parameters (severity scales, SpO2, respiratory and heart rate) | High risk | 21 patients with missing outcome data, imbalanced between groups; no motives reported |
| Incomplete outcome data (attrition bias) Other outcomes (adverse events, others) | High risk | 21 patients with missing outcome data, imbalanced between groups; no motives reported |
| Selective reporting (reporting bias) | Low risk | Published report includes all pre‐specified and expected outcomes; study protocol was not available |
| Other bias | Unclear risk | Duration of illness was significantly different in G + S group |
| Overall risk of bias | High risk | > 1 domain as high risk of bias |