2.

EMBASE search strategy

Numbers	Search strategy
1	Controlled study/
2	Clinical trial/
3	Major clinical study/
4	Randomized controlled trial/
5	Double blind procedure/
6	Clinical article/
7	random$.ti,ab,hw.
8	trial$.ti,ab,hw.
9	compar$.ti,ab,hw.
10	control$.ti,ab,hw.
11	study.ti,ab,hw.
12	follow$.ti,ab,hw.
13	clinic$.ti,ab,hw.
14	blind$.ti,ab,hw
15	placebo$.ti,ab,hw.
16	doubl$.ti,ab,hw.
17	1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16
18	Animal/
19	Nonhuman/
20	18 or 19
21	Human/
22	20 and 21
23	20 not 22
24	17 not 23
25	oxcarbazepine. ti,ab,hw.
26	trileptal. ti,ab,hw.
27	25 or 26
28	27 and 24
29	bipolar dis$.ti,ab,hw
30	bipolar affective dis$.ti,ab,hw
31	mania.ti,ab,hw
32	unipolar mania.ti,ab,hw
33	29 or 30 or 31 or 32
34	28 and 33 28 and 33 28 and 33