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. 2020 Jan 13;20:7. doi: 10.1186/s12876-019-1130-x

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Correlation analysis. A significant correlation was found between RCA, RPA and AST (RCA and RPA R = 0.976 P = 0.001; RPA and AST R = − 0.962 P = 0.001; RCA and AST R = -0.906 P = 0.005). The tacrolimus blood concentration was decreased as AST (R = 0.758 P = 0.046). Logistical regression analysis shows regression equation: T_C = 0.005AST + 7.223, T_D = − 0.007AST + 257.757, T_D = − 0.988TC + 263.219; T_D = − 0.494T_C-0.0035AST + 260.487. RPA (Ratio of proliferation to apoptosis), AST (asparatate aminotransferase), Tc (tacrolimus concentration), T_D (tacrolimus dose)