Table 2.
Changes in tacrolimus blood concentration (Tc) and RCA, RPA, AST after liver transplantation
| 0.5d | 1d | 2d | 3 d | 4d | 5d | 6d | |
|---|---|---|---|---|---|---|---|
| RCA | 0.269 ± 0.030 | 0.310 ± 0.021 | 0.452 ± 0.015 | 0.590 ± 0.041 | 0.621 ± 0.053 | 0.756 ± 0.049 | 0.789 ± 0.056 |
| RPA | 0.76 ± 0.089 | 0.88 ± 0.098 | 1.39 ± 0.01 | 4.8 ± 0.14* | 5.2 ± 0.25 | 6.5 ± 0.36 | 6.9 ± 0.49 |
| AST | 895.1 ± 168.8 | 1186.6 ± 378.2 | 1120.5 ± 298.5 | 599.1 ± 277.7* | 419.9 ± 201.2 | 227.6 ± 140.9 | 189.1 ± 110.3 |
| T C/D | 10.03 ± 1.15 | 11.46 ± 1.59 | 13.58 ± 2.01 | 12.21 ± 2.68 | 10.89 ± 2.35 | 8.01 ± 1.98 | 6.16 ± 1.24 |
*P < 0.01 versus 2 days, RCA (Ratio of CYP3A4 to actin), RPA(Ratio of proliferation to apoptosis), AST(asparatate aminotransferase), TC/D (tacrolimus blood concentration/dose ratio)