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. 2020 Jan 13;39:9. doi: 10.1186/s13046-019-1514-3

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The flow chart of clinical study. Patients qualified with our study criteria were prospectively enrolled, with written informed consent obtained before any treatment. Included patients were allocated to two groups based on the average IHC C3 score