Fig. 4.

Enhanced deposition of C3 in GC tissues predicts advanced tumor stage and poor prognosis. a Regional deposition of C3 in GC tissues was strongly associated with advanced T stage and TNM stage (P < 0.001); however, it was not correlated with pathological N stage and clinical TNM stage in the current GC cohort (P > 0.05); b The 5-year overall survival and disease-free survival curves based on C3 deposition in enrolled subjects and TCGA samples; c The overall survival differences according to various tumor stage in our dataset; d The ROC curves of oncologic outcome (cancer-related death) based on C3 deposition, baseline C3 depletion, pathologic TNM stage, tumor markers (CEA and CA19–9) and combined factors (C3 deposition plus CEA); e Forest plot of short-term surgical outcomes (postoperative morbidities), with relative risk (RR) compared between the two groups