Table 1.
The demographic and baseline characteristics of patients with gastric cancer
| The Pooled (n = 106) | Low C3 group (n = 41) | High C3 group (n = 65) | P-value | |
|---|---|---|---|---|
| Age, yrs | 56.4 ± 12.2 | 59.3 ± 10.5 | 54.6 ± 13.0 | 0.056 |
| ≤ 65 | 82 (77.4) | 31(75.6) | 51(78.5) | 0.813 |
| > 65 | 24 (22.6) | 10(24.4) | 14(21.5) | |
| Sex | 0.307 | |||
| Male | 65(61.3) | 28(68.3) | 37(56.9) | |
| Female | 41(38.7) | 13(31.7) | 28(43.1) | |
| BMI, kg/m2 | 21.6 ± 3.3 | 21.9 ± 3.6 | 21.4 ± 3.0 | 0.454 |
| Comorbidity | ||||
| HTN | 9 (8.5) | 5(12.2) | 4(6.2) | 0.303 |
| DM | 4 (3.8) | 0 | 4(6.2) | 0.157 |
| Smoke | 26 (24.5) | 8(19.5) | 18(27.7) | 0.366 |
| Alcohol abuse | 13 (12.3) | 4(9.8) | 9(13.8) | 0.762 |
| C3 level, mg/mL | 0.87 ± 0.2 | 1.06 ± 0.19 | 0.75 ± 0.14 | < 0.001 |
| C4 level, mg/mL | 0.23 ± 0.1 | 0.25 ± 0.07 | 0.21 ± 0.06 | 0.003 |
| Albumin level, g/dL | 38.1 ± 7.5 | 37.6 ± 8.8 | 38.3 ± 6.6 | 0.634 |
| Total bilirubin, μmol/L | 10.1 ± 4.7 | 10.7 ± 5.1 | 9.6 ± 4.4 | 0.191 |
| ASA grade | 0.118 | |||
| I + II | 85 (80.2) | 36(87.8) | 49(75.4) | |
| ≥ III | 21 (19.8) | 5(12.2) | 16(24.6) | |
| Tumor location | 0.187 | |||
| GEJ | 5(4.7) | 4(9.8) | 1(1.5) | |
| Upper 1/3 | 27(25.5) | 8(19.5) | 19(29.2) | |
| Middle 1/3 | 28(26.4) | 12(29.3) | 16(24.6) | |
| Lower 1/3 | 46(43.4) | 17(41.4) | 29(44.7) | |
| Depth of invasion | 0.518 | |||
| pT1 | 8 (7.6) | 4(9.8) | 4(6.2) | |
| pT2 | 11 (10.3) | 5(12.2) | 6(9.2) | |
| pT3 | 9 (8.5) | 5(12.2) | 4(6.2) | |
| pT4 | 78 (73.6) | 27(65.8) | 51(78.4) | |
| Lymph nodes metastasis | 0.474 | |||
| pN0 | 32 (30.2) | 13(31.7) | 19(29.2) | |
| pN1 | 14 (13.2) | 6(14.6) | 8(12.3) | |
| pN2 | 20 (18.9) | 10(24.4) | 10(15.4) | |
| pN3 | 40 (37.7) | 12(29.3) | 28(43.1) | |
| Histopathological type | 0.046 | |||
| Well diff. | 7 (6.6) | 3(7.3) | 4(6.2) | |
| Moderate diff. | 19 (17.9) | 12(29.3) | 7(10.8) | |
| Poor diff. | 80 (75.5) | 26(63.4) | 54(83.0) | |
| Pathological Stage (AJCC 7th ed.) | 0.414 | |||
| I | 12 (11.3) | 7(17.1) | 5(7.7) | |
| II | 25 (23.6) | 8(19.5) | 16(24.6) | |
| III | 55 (51.9) | 22(53.7) | 34(52.3) | |
| IV | 14 (13.2) | 4(9.8) | 10(15.4) | |
| Neo-adjuvant chemotherapy | 3(2.8) | 1(2.4) | 2(3.1) | 0.847 |
| Adjuvant therapy | 78(73.6) | 28(68.3) | 50(76.9) | 0.326 |
Data present with mean ± SD or number (percentage). Cut-off value for Low/High C3 group is 1.0 IHC C3 score. Abbreviations: BMI, body mass index; HTN, hypertension; DM, diabetes mellitus; ASA, American society of anesthesia; diff., differentiation.