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. 2019 Nov 26;295(2):458–467. doi: 10.1074/jbc.RA119.008522

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© 2020 Xiao et al.

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Figure 3. — ¹³C chemical shift and secondary structural profile of SPA. a–c, secondary ¹³C chemical shifts obtained by SSNMR for ¹³C_β (a), ¹³C_α (b), and ¹³CO (c) in the SPA form of Aβ42 (40). d, dihedral angles (ϕ, ψ) obtained by the TALOS-N software according to the ¹³C chemical shift analysis (Table S2) of Aβ42 in the SPA form (41). As shown in the top region of d, the secondary structure analysis performed by the TALOS software identified two β-strand regions (green arrows) separated by loop/turn regions (blue wave) at residues 22–29.