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. 2019 Nov 19;295(2):415–434. doi: 10.1074/jbc.RA118.007212

Figure 8.

Figure 8.

A–E, scatter plot depicting body weight, heart weight to tibia length ratio (HW/TL), left-ventricular posterior wall thickness, left-ventricular internal diameter (LVID), and cardiac contractile functions, respectively, of WT and SIRT6+/− mice, before and after the treatment with SB-505124. SB-505124 was injected intraperitoneally at a concentration of 10 mg/kg every alternate day for 15 days. Sterile peanut oil was used as the vehicle. n = 5. *, p < 0.05. One-way ANOVA test was used to calculate the p values. F, Western blot analysis of heart lysates from WT and SIRT6+/− mice, before and after the treatment with SB-505124 (10 mg/kg). Error bars, S.D.