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. 2020 Jan 13;27:5. doi: 10.1186/s12929-019-0593-y

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Collagen XVII is essential for increased glycolysis of lung cancer cells. a, Lung cancer cells A549 with collagen XVII overexpression (Col XVII OE) showed increased ECAR compared to parental cells. b and c, The glucose uptake and lactate assay showed increased glucose consumption and lactate production in cells with collagen XVII overexpression. d, Decreased ECAR was observed in lung cancer with collagen XVII knockdown (Col XVII KD). e and f, The glucose uptake and lactate assay showed decreased glucose consumption and lactate production in cells with collagen XVII knockdown