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. Author manuscript; available in PMC: 2020 Jan 26.
Published in final edited form as: Science. 2019 Jul 11;365(6451):382–386. doi: 10.1126/science.aax7063

Figure 2: Phenotypic outcomes of RESCUE on cell growth and signaling.

Figure 2:

A. Schematic of β-catenin domains and RESCUE targeting guide.

B. Schematic of β-catenin activation and cell growth via RESCUE editing.

C. Percent editing by RESCUE at relevant positions in the CTNNB1 transcript.

D. Activation of Wnt/β-catenin signaling by RNA editing as measured by β-catenin-driven (TCF/LEF) luciferase expression.

E. Representative microscopy images of RESCUE CTNNB1 targeting and non-targeting guides in HEK293FT cells.

F. Quantitation of cellular growth due to activation of CTNNB1 signaling by RNA editing in HEK293FT cells.