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. Author manuscript; available in PMC: 2020 Jan 13.
Published in final edited form as: Bioorg Med Chem Lett. 2014 Jun 2;24(16):4039–4043. doi: 10.1016/j.bmcl.2014.05.074

Scheme 1.

Scheme 1.

Synthesis of 2-halo and 2-methyl derivatives. Reagents and conditions: (a) BH3–SMe2 in THF, 80–90%; (b) Compound 7, EDC, HOBt, TEA, CH3CN, 70–80%; (c) LiAlH4, THF, 75%; (d) DPPA, NEt3, toluene, 72%; (e) PPh3, H2O, 85%.