Figure FIG. 4.

Effect of exogenous rCCN2 and rCCN3 on the proliferation, proteoglycan synthesis/maturation, and calcification of chondrocytes. (A and B) A comparative analysis of effects of rCCN2 and rCCN3 on the proliferation and proteoglycan synthesis between CCN2‐KO and WT chondrocytes. (C) Effects of rCCN2 and rCCN3 on the morphology, ECM accumulation, and mineral deposition of WT chondrocytes was evaluated. (D and E) A quantitative data of C is shown in graphic form. Data are the mean ± SE of two independent experiments. Chondrocytes were harvested from eight WT and eight CCN2‐KO mice. *p < 0.05, significantly different from WT control. ^† p < 0.05, significantly different from CCN2‐KO control.