Summary of findings 8. Antibiotics versus placebo for maintenance therapy.
| Antibiotics versus placebo for maintenance therapy | |||||
|
Patient or population: adults with renal vasculitis for maintenance therapy
Settings: inpatients then outpatients
Intervention: antibiotics Comparison: placebo | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| Placebo | Antibiotics | ||||
| Death at 6 months | 25 per 1000 |
8 per 1000 (0 to 194) |
RR 0.33 (0.01 to 7.76) |
81 (1) | ⊕⊕⊝⊝ low1 |
| Kidney function | not reported | not reported | ‐‐ | ‐‐ | ‐‐ |
| Dialysis | not reported | not reported | ‐‐ | ‐‐ | ‐‐ |
| Remission at one year | 796 per 1000 | 908 per 1000 (780 to 1000) | RR 1.14 (0.98 to 1.33) | 111 (2) | ⊕⊕⊝⊝ low2,3 |
| Relapse | not reported | not reported | ‐‐ | ‐‐ | ‐‐ |
| Adverse events causing study drug discontinuation | 50 per 1000 |
195 per 1000 (44 to 863) |
RR 3.90 (0.88 to 17.26) |
81 (1) | ⊕⊕⊝⊝ low1 |
| Infection (urinary tract infection) | 25 per 1000 |
8 per 1000 (0 to 194) |
RR 0.33 (0.01 to 7.76 |
81 (1) | ⊕⊕⊝⊝ low1 |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1Downgrade 2 levels for study size and limitations with risk of bias assessment 2 One study had multiple limitations in the reporting of the study design 3 Two small studies