Comparison 2. Pulse versus continuous cyclophosphamide.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Three months	2	181	Risk Ratio (M‐H, Random, 95% CI)	0.69 [0.10, 4.73]
1.2 Six months	2	181	Risk Ratio (M‐H, Random, 95% CI)	0.61 [0.22, 1.69]
1.3 One year	3	231	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.34, 1.31]
1.4 Two years	3	129	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.21, 2.61]
1.5 Death at final follow‐up	4	278	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.44, 1.32]
2 Kidney function: serum creatinine	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 One month	0	0	Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Two months	0	0	Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
2.3 Three months	1	28	Mean Difference (IV, Random, 95% CI)	‐4.58 [‐97.77, 88.61]
2.4 Six months	1	27	Mean Difference (IV, Random, 95% CI)	51.69 [‐81.03, 184.41]
2.5 Twelve months	2	52	Mean Difference (IV, Random, 95% CI)	‐9.78 [‐53.16, 33.61]
2.6 Two years	2	51	Mean Difference (IV, Random, 95% CI)	4.46 [‐67.90, 76.82]
3 Dialysis	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 Three months	1	137	Risk Ratio (M‐H, Random, 95% CI)	2.71 [0.11, 65.43]
3.2 Six months	2	176	Risk Ratio (M‐H, Random, 95% CI)	7.02 [0.90, 54.80]
3.3 Twelve months	1	117	Risk Ratio (M‐H, Random, 95% CI)	3.55 [0.41, 30.80]
3.4 Dialysis end of study	4	245	Risk Ratio (M‐H, Random, 95% CI)	1.90 [0.92, 3.91]
4 Remission	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Three months	1	137	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.81, 1.30]
4.2 Six months	2	176	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.93, 1.13]
4.3 Nine months	1	121	Risk Ratio (M‐H, Random, 95% CI)	0.97 [0.92, 1.02]
4.4 Twelve months	1	117	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.94, 1.03]
4.5 Eighteen months	1	116	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.94, 1.03]
4.6 Untimed	1	47	Risk Ratio (M‐H, Random, 95% CI)	1.18 [0.98, 1.42]
5 Relapse	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 One year	2	164	Risk Ratio (M‐H, Random, 95% CI)	1.45 [0.57, 3.69]
5.2 Two years	1	47	Risk Ratio (M‐H, Random, 95% CI)	1.89 [0.51, 7.03]
5.3 Untimed	4	235	Risk Ratio (M‐H, Random, 95% CI)	1.79 [1.11, 2.87]
6 Treatment failure	2	82	Risk Ratio (M‐H, Random, 95% CI)	1.36 [0.15, 12.56]
7 Adverse events	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
7.1 Serious infections	4	278	Risk Ratio (M‐H, Random, 95% CI)	0.71 [0.38, 1.33]
7.2 Leukopenia	4	278	Risk Ratio (M‐H, Random, 95% CI)	0.53 [0.36, 0.77]
7.3 Nausea	2	97	Risk Ratio (M‐H, Random, 95% CI)	2.51 [1.07, 5.89]