2.

AIIRA versus placebo/no treatment

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	5	3409	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.85, 1.17]
2 Cardiovascular mortality	0		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
3 Doubling of serum creatinine	3	3251	Risk Ratio (M‐H, Random, 95% CI)	0.79 [0.67, 0.93]
4 End‐stage kidney disease	3	3251	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.67, 0.91]
5 Micro‐ to macroalbuminuria	3	761	Risk Ratio (M‐H, Random, 95% CI)	0.49 [0.32, 0.75]
6 Micro‐ to normoalbuminuria	2	670	Risk Ratio (M‐H, Random, 95% CI)	1.42 [1.05, 1.93]
7 Cough	2	194	Risk Ratio (M‐H, Random, 95% CI)	4.93 [1.00, 24.35]
8 Headache	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
9 Impotence	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
10 Hyperkalaemia	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected