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. 2006 Oct 18;2006(4):CD006257. doi: 10.1002/14651858.CD006257
Methods Country: Hong Kong 
 Setting/Design: Teaching hospitals 
 Time frame: NS 
 Randomisation method: NS 
 Blinding 
 ‐ Participants: No 
 ‐ Investigators: No 
 ‐ Outcome assessors: No 
 ‐ Data analysis: No 
 Intention‐to‐treat: Yes 
 Follow‐up period: 1 year 
 Loss to follow‐up: 1
Participants Inclusion criteria
  • DM: Type 2 Normal renal function or early stage nephropathy


Enalapril group
  • Number: 20

  • Age: 59.7 (11.8)

  • Sex (M/F): 9/13


Valsartan group
  • Number: 22

  • Age: 62.1 (10.5)

  • Sex (M/F): 12/8


Exclusion criteria
  • Uncontrolled hypertension (sitting BP > 200/115 mm Hg)

  • History of MI

  • CVA

  • Uncontrolled CHF within the previous 6 months

  • Significant renal impairment (SCr > 150 µmol/L)

Interventions Enalapril group 
 5‐10 mg/d
Valsartan group 
 80‐160 mg/d
Co‐interventions 
 Other antihypertensive agents
Outcomes
  1. BP

  2. AER

Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear