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. 2006 Oct 18;2006(4):CD006257. doi: 10.1002/14651858.CD006257

Parving 2001a

Methods Country: Denmark 
 Setting/Design: Hospital 
 Time frame: NS 
 Randomisation method: Yes 
 Blinding 
 ‐ Participants: No 
 ‐ Investigators: No 
 ‐ Outcome assessors: No 
 ‐ Data analysis: No 
 Intention‐to‐treat: Yes 
 Follow‐up period: 96 months 
 Loss to follow‐up: 18
Participants Inclusion criteria

  • DM: Type 1 (onset of diabetes before 41 years)

  • Age: < 50 years

  • Persistent albuminuria: < 300 mg/24 h

  • SCr: < 120 µmol/L

  • GFR: > 60 mL/min/1.73 m²

  • BP: Average of 3 or more consecutive readings < 159/90 mm Hg


Captopril group

  • Number: 16

  • Age: 32 (8)

  • Sex (M/F): 10/5


Control group

  • Number: 17

  • Age: 30 (8)

  • Sex (M/F): 13/5


Exclusion criteria

  • Oedema

  • Drugs (except oral contraceptives)
Interventions Captopril group 
 12.5‐125 mg/d
Control group
Co‐interventions 
 Diuretics, dihydropyridine, CCB, beta‐blocker
Outcomes

  1. BP

  2. Albuminuria

  3. GFR
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear