Rizzoni 2005

Methods	Country: Italy Setting/Design: Multicentre Time frame: NS Randomisation method: NS Blinding ‐ Participants: No ‐ Investigators: No ‐ Outcome assessors: No ‐ Data analysis: No Intention‐to‐treat: No Follow‐up period: 1 year Loss to follow‐up: 0
Participants	Inclusion criteria Mild essential hypertension DM: Type 2 with or without ongoing oral hypoglycaemic therapy Age: 30‐70 years Enalapril group Number: 7 Age: 58 (4) Sex (M/F): 5/2 Candesartan group Number: 8 Age: 58 (9) Sex (M/F): 6/2 Exclusion criteria Previous treatment with ACEi and AIRA Secondary forms of hypertension or any disease that could have interfered with the study protocol
Interventions	Enalapril group 10‐20 mg/d Candesartan group 8‐16 mg/d Co‐interventions Diuretics if BP not controlled in 12 weeks
Outcomes	Indices of subcutaneous small resistance artery structure Endothelium function Death rates
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear