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. 2006 Oct 18;2006(4):CD006257. doi: 10.1002/14651858.CD006257
Methods Country: Italy 
 Setting/Design: University 
 Time frame: NS 
 Randomisation method: Yes 
 Blinding 
 ‐ Participants: No 
 ‐ Investigators: No 
 ‐ Outcome assessors: No 
 ‐ Data analysis: No 
 Intention‐to‐treat: Yes 
 Follow‐up period: 6 months x 2 
 Loss to follow‐up: 0
Participants Inclusion criteria
  • DM: Type 2

  • Persistent albuminuria: > 300 mg/24 h on at least 3 occasions


Enalapril group
  • Number: 12

  • Age: 46.9 (9.1)

  • Sex (M/F): 6/6


Atenolol group
  • Number: 12

  • Age: 46.9 (9.1)

  • Sex (M/F): 6/6


Exclusion criteria
  • Signs of other renal disease

Interventions Enalapril group 
 5 mg/d
Atenolol group 
 50 mg/d
Co‐interventions: NS
Outcomes
  1. BP

  2. GFR

  3. AER

Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear