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. 2006 Oct 18;2006(4):CD006257. doi: 10.1002/14651858.CD006257
Methods Country: India 
 Setting/Design: University 
 Time frame: NS 
 Randomisation method: NS 
 Blinding 
 ‐ Participants: Yes 
 ‐ Investigators: No 
 ‐ Outcome assessors: No 
 ‐ Data analysis: No 
 Intention‐to‐treat: No 
 Follow‐up period: 5 years 
 Loss to follow‐up: 13
Participants Inclusion criteria
  • Age: 43‐55 years

  • Known duration of diabetes < 15 years

  • No history and clinical or laboratory evidence of non‐diabetic renal, systemic, cardiac or hepatic diseases

  • BMI < 27 kg/m²

  • Normal BP values on 2 consecutive examinations (SBP </= 140 mm Hg; DBP </= 90 mm Hg)

  • GFR > 90 mL/min

  • AER of 20‐200 µg/min on 2 consecutive visits without evidence of UTI


Enalapril group 1
  • Number: NS

  • Age: NS

  • Sex(M/F): NS


Enalapril group 2
  • Number: NS

  • Age: NS

  • Sex(M/F): NS


Exclusion criteria: NS
Interventions Enalapril group 1 
 10 mg/d
Enalapril group 2 
 Moderate treatment
Co‐interventions: No
Outcomes
  1. AER

  2. GFR

  3. BP

Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear