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. 2018 Mar 30;2018(3):CD003317. doi: 10.1002/14651858.CD003317.pub3

Hopwood 2008.

Methods RCT, computer‐generated random number list stratified with BI
 C: sequentially numbered, sealed, opaque envelopes
 Blinding: outcome assessors
 ITT analysis: yes
 Numbers of withdrawals: 10 in acupuncture group, 3 in control group
Numbers of losses to FU: 2 in acupuncture group, 4 in control group
Participants Country: UK
 92 participants (42.8% male, age not reported) with acute ischemic stroke completed treatment.
Treatment: 47, control: 45
 Between 4 and 10 days from stroke onset
 50% CT scan before entry
Health conditions before stroke: without previous stroke or TIA, serious comorbidity, cardiac pacemaker
 Comparability: age, SSS score, and BI similar
Interventions Treatment group: 10 acupoints on paralyzed side, manual (GB20, GB31, GB43, etc.) or electrical stimulation (LI10, SJ5, GB34), 30 minutes/session, 3 times per week for 4 weeks
 Control group: placebo acupuncture (deactivated TENS)
Both groups: drug therapy, routine physiotherapy, and occupational therapy
Outcomes BI, Motricity Index, NHP at entry, 3, 6, 12, 24, and 52 weeks
 Place of residence at 24 and 52 weeks
Adverse events
Notes FU: 1 year
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated random number list stratified with BI
Allocation concealment (selection bias) Low risk Sequentially numbered, sealed, opaque envelopes
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Participants not blinded to treatment
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Blinding of outcome assessors
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 13 in acupuncture group and 12 in control group lost to follow‐up
Selective reporting (reporting bias) Unclear risk Insufficient information to permit judgement
Other bias Unclear risk Insufficient information to permit judgement