| Methods |
Location: Italy
Participants were randomly assigned to treatment. The actual randomisation is not clear. No description of blinding |
| Participants |
50 adult participants with acute purulent exacerbation of chronic bronchitis caused by H. influenzae were recruited. Participants: azithromycin group N = 25, amoxycillin/clavulanic acid group N = 25 |
| Interventions |
1. Azithromycin 500 mg once daily for 3 days
2. Amoxicillin/clavulanic acid 1 g twice daily for 6 days |
| Outcomes |
Cure
Pathogen eradication |
| Notes |
All 50 randomised participants were clinically and bacteriological evaluated |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Participants were randomly assigned to treatment. The actual randomisation is not clear |
| Allocation concealment (selection bias) |
Unclear risk |
No description of allocation method |
| Blinding (performance bias and detection bias)
All outcomes |
Unclear risk |
No description of blinding |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
All randomised participants were evaluated |
| Selective reporting (reporting bias) |
Unclear risk |
The study protocol is not available |
| Other bias |
Unclear risk |
Baseline characteristics of the 2 treatment groups were not addressed |
