Table 2.

Coefficients and hazard ratios (HRs) associated with the 16 variables selected by elastic net as prognostic for G3+ RICT.

Variable	Coefficient (log(HR))	HR
PCD	1.113	3.043
MHD (per 10 Gy)	0.180	1.197
miR-100–5p	−0.006	0.994
miR-106b-5p	−0.080	0.924
miR-145–5p	−0.176	0.839
miR-146a-5p	−0.598	0.550
miR-192–5p	−0.282	0.754
miR-195–5p	−0.150	0.861
miR-223–3p	−0.033	0.968
miR-25–3p	−0.191	0.826
miR-34a-5p	−0.325	0.722
miR-574–3p	0.616	1.851
miR-885–5p	0.499	1.647
Iet-7c	0.284	1.328
miR-200b-3p	0.501	1.651
miR-134	0.086	1.089

HR for miRNAs represents change in risk associated with in 1 crease in serum concentration 1 standard deviation above the mean value for that miRNA among all patients.

HR = hazard ratio. PCD = pre-existing cardiac disease. MHD = mean heart dose.