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. 2020 Jan 8;13:185–197. doi: 10.2147/OTT.S229577

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© 2020 Huang et al.

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Effects of UBE4B silencing on the cell cycle and apoptosis of of ACHN and SKRC39 cells. (A, B) Effect of UBE4B knockdown on the cell cycle was determined using flow cytometry. UBE4B overexpression caused G₀/G₁ phase arrest in ACHN (A) and SKRC39 (B) cells. (C, D) Effect of UBE4B knockdown on apoptosis of RCC cells was determined with Annexin V-propidium iodide (PI) staining method. Apoptosis rates were not significantly different between ACHN(C) and SKRC39(D) cells transfected with siUBE4B and those transfected with siNC. P values were calculated using Student’s t-test. *P<0.05, **P<0.01, and ***P<0.001, versus cells transfected with siNC. siNC represents negative control small interfering RNAs.