Table 3.
Univariate and Multivariate Analysis of Overall Survival in ccRCC
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | 1.009 (0.974–1.046) |
0.603 | — | — |
| Gender (female vs Malea) |
2.505 (1.063–5.902) |
0.036* | 2.374 (0.884–6.089) |
0.087 |
| Tumor size (≥ 5 vs < 5 cma) |
3.616 (1.325–9.873) |
0.012* | 2.374 (0.690–8.165) |
0.170 |
| Fuhrman grade (Ⅲ-Ⅳ vs.Ⅰ-Ⅱa) |
2.642 (1.065–6.559) |
0.036* | 0.668 (0.227–1.961) |
0.668 |
| TNM stage (III + IV vs I + IIa) |
11.971 (4.936–29.013) |
<0.001* | 0.434 (0.078–2.401) |
0.339 |
| AFP | 0.918 (0.686–1.229) |
0.566 | — | — |
| Hematuria (positive vs negativea) |
0.396 (0.133–1.178) |
0.096 | — | — |
| Albuminuria (positive vs negativea) |
0.691 (0.161–2.970) |
0.620 | — | — |
| Renal capsular invasion (positive vs negativea) |
0.343 (0.640–3.615) |
0.343 | — | — |
| UBE4B (high vs lowa) |
7.477 (2.201–25.396) |
0.001* | 4.470 (1.121–17.829) | 0.034* |
| Distant metastasis (positive vs negativea) |
27.272 (10.392–71.570) | <0.001* | 34.945 (7.220–169.138) | <0.001* |
Notes: *P < 0.05 was considered statistically significant. aReference group.
Abbreviations: HR, hazard ratio; CI, confidence interval; AFP, alfa fetoprotein; TNM, tumor, node, metastasis.