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. 2020 Jan 9;51:102619. doi: 10.1016/j.ebiom.2019.102619

Corrigendum Table 2.

Association between EPA+DHA concentrations and risk of early preterm birth. Shown are results for EPA+DHA measurements based on all 1st trimester samples (Panel A-i), based on 1st trimester samples but including only those samples that had never been thawed (Panel A-ii), based on all 2nd trimester samples (Panel B-i), and based on 2nd trimester samples but including only those samples that had never been thawed (Panel B-ii).

Controls Cases Crude
 Adjusted for thawing and temperature1
 Controls Cases Further adjusted for covariates2
OR (95% CI) P-Value OR (95% CI) P-Value OR (95% CI) P-Value
A-i: 1st trimester samples
 All included (unselected)
Test for association in spline regression .. < 0.0001 .. 0.90 .. 0.98
Test for linear v. spline association .. 0.0002 .. 0.78 .. 0.92
EPA + DHA categorized into quintiles .. < 0.0001 .. 0.41 .. 0.30
 Q1: 0.37 – 1.48 67 192 5.54 (3.86; 8.02) < 0.0001 1.29 (0.73, 2.23) 0.38 67 192 1.24 (0.68, 2.25) 0.48
 Q2: 1.48 – 1.81 67 71 2.05 (1.36; 3.09) 0.0006 0.84 (0.47, 1.49) 0.57 67 71 0.74 (0.40, 1.36) 0.34
 Q3+4+5: 1.81 – 4.74 199 103 1 .. 1 .. 199 103 1 1
A-ii: 1st trimester samples
 Analysis restricted to never thawed
Test for association in spline regression .. 0.36 .. 0.69 ..
Test for linear v. spline association .. 0.56 .. 0.53 ..
EPA + DHA categorized into quintiles3 .. 0.26 .. 0.88 ..
 Q1: 0.37 – 1.48 53 9 0.57 (0.25; 1.18) 0.13 0.87 (0.37, 1.91) 0.74
 Q2: 1.48 – 1.81 56 12 0.72 (0.35; 1.40) 0.34 0.85 (0.40, 1.72) 0.66
 Q3+4+5: 1.81 – 4.74 188 56 1 .. 1 ..
B-i: 2nd trimester samples
 All included (unselected)
Test for association in spline regression .. < 0.0001 .. 0.026 .. 0.10
Test for linear v. spline association .. < 0.0001 .. 0.033 .. 0.069
EPA + DHA categorized into quintiles .. < 0.0001 .. 0.035 .. 0.064
 Q1: 0.47 – 1.42 68 226 9.33 (6.42; 13.74) < 0.0001 2.13 (1.18, 3.79) 0.01 68 226 1.92 (1.02, 3.60) 0.045
 Q2: 1.43 – 1.74 69 67 2.73 (1.78; 4.20) < 0.0001 1.12 (0.57, 2.14) 0.73 69 67 0.90.(0.45, 1.79) 0.78
 Q33+4+5: 1.74 – 4.95 205 73 1 .. 1 .. 205 73 1 ..
B-ii: 2nd trimester samples
 Analysis restricted to never thawed
Test for association in spline regression .. 0.10 .. 0.36 ..
Test for linear v. spline association .. 0.073 .. 0.23 ..
EPA + DHA categorized into quintiles3 .. 0.18 .. 0.16 ..
 Q1: 0.47 – 1.42 61 17 1.87 (0.95; 3.58) 0.070 1.95 (0.98, 3.78) 0.056
 Q2: 1.43 – 1.74 64 13 1.36 (0.65; 2.72) 0.40 1.23 (0.58, 2.50) 0.58
 Q33+4+5: 1.74 – 4.95 201 30 1 .. 1 ..
1

Analyses were adjusted for differences in thawings (0, 1, 2 times) and temperatures (-20, -80, -196°C); for the analyses restricted to samples that had never been thawed (Panels A-ii and B-ii), analyses were adjusted for temperatures.

2

Further adjusted for covariates: Maternal age, maternal height, parity, maternal pre-pregnancy BMI, SES, cohabitation, residence and smoking; coded as in the original article. For the analyses restricted to samples that had never been thawed (Panels A-ii and B-ii), entering all the covariates simultaneously into the model was not possible due lack of convergence; however, taking the covariates in one by one was passible, and this had only limited effect on the estimates of association (data not shown but available from the authors).

3

Cut points for defining quintiles of the samples that had never been thawed (Panel A-ii), are based on the ‘unselected’ controls (Panel A-i).