Figure 7.

In vivo inhibition of tumor growth by administration of MNPs with combind thermo- and chemo-therapy. (A) Nude mice treatment scheme. (B) Tumor-bearing mice images before AMF treatment and 36 days after AMF treatment. (C) The curve of tumor volume (V/V_initial) after MNPs-mediated AMF treatment. (D) Cumulative survival rate of nude mice injected with NPs. Subcutaneous tumors after injection with saline, HSPI&Fe₃O₄@SiNPs and CD20-HSPI&Fe₃O₄@SiNPs. (E) H&E-stained tumor tissue sections of control and CD20-HSPI&Fe₃O₄@SiNP-treated mice at 36 days after AMF treatment. (F) TEM images of tumor tissue in mice treated with saline and CD20-HSPI&Fe₃O₄@SiNPs by i.v. injection. Nanoparticles accumulated in the tumor tissue, which was seriously damaged after 36 days of AMF treatment. (G) Fe element content in organs showed the biodistribution of the MNPs in mouse after 24 h i.v. injection. Experiments were performed three times (n = 10).