Figure 5.

Studies of AGuIX® NPs on lung cancer rodent model. A. Ultrashort echo time MRI axial slices of the H358‐Luc lung tumor-bearing mice before (1) and after iv administration of 200 μL of 50 mM [Gd³⁺] AGuIX® NP (2) or ot administration of 50 μL of 50 mM [Gd³⁺] AGuIX® NP (3). The presence and colocalization of the tumor was assessed with BLI (4). In (4) the scale colors are proportional to the number of detected photons per second. The arrow shows the tumor in the left lung. B. Bar plot comparing the SE (red, left scale) and the ΔCNR (blue, right scale) for ot and iv administration of AGuIX® NP and Dotarem®. *: p < 0.05. Data are expressed as the means ± standard error of the mean. The ΔCNR was computed as the difference between the CNR before and after the administration of AGuIX® NP or Dotarem®. C. Curves of SE using ultrashort echo time MRI (red, left scale) and CNR (blue, right scale) after ot (50 μL of 50 mmol/L [Gd³⁺]) (1) or iv (200 μL of 50 mmol/L [Gd³⁺]) (2) administration of AGuIX® NPs. These graphs show the different pharmacokinetics observed after the two administration routes. Dashed lines exhibit the curves trend. Data are expressed as the means ± standard error of the mean. D. Survival curve comparison of tumor‐bearing mice without treatment (n = 6), only treated by irradiation (n = 11), and treated by irradiation (n = 11) 24 h after ot administration of AGuIX® NPs, 161 days after tumor implantation. The irradiation was performed at 10 Gy, 37 days after tumor implantation. Adapted with permission from ref 48-49, copyrights 2019 John Wiley and Sons and National Academy of Sciences.