Figure 13.

(A) Schematic of the structure of NSC@mSiO2-SNO/ICG NPs and their passive accumulation in tumors via the EPR effect. (B) X-ray radiation on this system would trigger multiple tumoricidal responses by: (I) increasing dose deposition to accelerate radiolysis, (II) producing cytotoxic ROS by activating ICG based on the scintillation effect of NSC, and (III) releasing high levels of NO due to radiation fracture of S-N bonds. Adapted with permission from Ref 57. Copyright 2018 Ivyspring Publisher.