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. 2020 Jan 1;10(3):1122–1135. doi: 10.7150/thno.37851

Figure 5.

Figure 5

Selective inhibition of PDGFRβ differentially affects tumor pericyte populations in LLC and B16/PDGF-BB tumors. LLC (A, C, E) and B16/PDGF-BB (B, D, F) tumors were grown in ASKA PDGFRβ mutant mice after treatment with vehicle, 1-NaPP1 or imatinib for 10 consecutive days; sections from tumors were co-immunostained for CD31/podocalyxin and PDGFRβ. PDGFRβ+ pericyte coverage was quantified in LLC (A; CD31, green; PDGFRβ, red) and B16/PDGF-BB (B; podocalyxin, red; PDGFRβ, green). CD31 and α-SMA were co-immunostained and α-SMA+ pericyte coverage quantified in LLC (C) and B16/PDGF-BB (D) tumors (CD31, green; α-SMA, red). Podocalyxin or CD31 and NG2 were co-immunostained and NG2+ pericyte coverage quantified in LLC (E) and B16/PDGF-BB (F) tumors (LLC: CD31, green; NG2, red; B16/PDGF-BB: podocalyxin, red; NG2, green). >20 field 200x magnification images were scored for each mouse (n=5 or more animals). Scale bar, 50 µm. *p<0.05, **p<0.01 and ***p<0.001.