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. 2020 Jan 1;10(3):1245–1261. doi: 10.7150/thno.40060

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Perinatal exposure to low doses of PBDE-47 results in hippocampal neuronal apoptosis and loss associated with mitochondrial fusion and fission dynamics disruption in adult female rats. (A) Representative images and quantification of Nissl staining and caspase-3 immunostaining (black arrows) of hippocampal CA1 region in female rats. n=3 rats/group. Scale bar, 500 μm (top panel), 50 μm (bottom panel). (B) Representative western blotting and quantification of active caspase-3 of hippocampus in female rats. n=6 rats/group. (C) Representative images and quantification of immunohistochemical staining (black arrows) for Fis1 and Mfn2 of hippocampal CA1 region in female rats. n=3 rats/group. Scale bar, 500 μm. (D) Representative western blotting and quantification of Fis1 and Mfn2 of hippocampal tissues in female rats. n=6 rats/group. Results are expressed as mean ± SD. *P < 0.05 versus control group.