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. 2020 Jan 1;10(3):998–1015. doi: 10.7150/thno.40076

Figure 3.

Figure 3

ZDHHC17 and MAP2K4 Expression Correlates with Glioma Tumor Grade and has Prognostic Significance. (A) Representative images of immunohistochemistry staining for ZDHHC17 and MAP2K4 in different grade gliomas and normal brain specimens. Scale bar, 100 µm. (B, C) Correlation between MAP2K4 and ZDHHC17 (B) or ZDHHC13 (C) in GBM using TCGA datasets. Correlation statistical significance was evaluated using a linear regression model (n = 171, r = 0.4394, p < 0.001) (B), (n = 172, r = -0.07494, p = 0.3286) (C). (D-G) Accumulative overall (D; F, n=164) and disease-free survival (E; G, n=118) of patients with high or low ZDHHC17 (D, E) or MAP2K4 (F, G) expression GBM (based on IHC staining results) calculated using the Kaplan-Meier method and compared with the log-rank test for the same set of patients (*p < 0.05; **p < 0.01).