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. 2020 Jan 1;10(3):1262–1280. doi: 10.7150/thno.38834

Figure 3.

Figure 3

ROS/redox imbalance in liver diseases. (A) Apoptosis, or programmed cell death; (B) Liver tumor cells have higher oxidation/antioxidant levels, after use of chemotherapy drugs, induces cell death by increasing ROS levels; (C) ROS in liver transplantation. Upon reperfusion, KCs are activated and dramatically release oxygen free radicals, which leads to liver damage; (D-E): HBV and HCV induce chronic hepatitis and liver fibrosis through enhancing oxidative stress response.