Figure 2.

The role of the BVZ/IFN and ERLO combination on RCC xenograft tumor growth. (A) 5.10⁶ cells 786-O cells were subcutaneously injected into nude mice. Seven days after injections all mice developed tumors. 31 days after cell injection (start treatment), mice were treated twice a week with control or ERLO (E, 50 mg/kg) or BVZ (B, 7.5 mg/kg) plus IFN (I, 9MIU) plus or minus ERLO (50 mg/kg). The tumor volume is presented as the means ± s.d. (n = 10). Statistical differences to the untreated mice are shown: *p <0.05; *** p<0.001. (B) Same experiment as described in a but using A498 cells. * p < 0.05; ** p< 0.01; *** p< 0.001. * p < 0.05; *** p < 0.001. (C) Images of the 786-O tumors at the end of the experiments. (D) Images of A498 tumors at the end of the experiment.