Table 1.

Analysis of pro-angiogenic/pro-lymphangiogenic/pro-inflammatory genes/proteins in tumors from mice treated with ERLO, BVZ/INF or BVZ/INF/ERLO.

The percentage expression of the different genes evaluated by qPCR and the amounts of cytokines detected by ELISA are shown. The indication “m” stands for mouse genes. If not indicated the genes are human ones. For the measured genes, the reference values (100) correspond to the content of a given gene in tumors of the placebo-treated mice. The amounts of cytokine in tumor extracts are given in picograms (pg) or nanograms (ng) per milligrams (mg) of total protein. The statistically significant differences are shown. * p < 0.05: ** p < 0.01:*** p < 0.001. A good prognostic marker is presented in black characters on a grey background; a poor prognostic marker is presented in white characters on a black background and markers with no significant modification are presented in black characters on a white background. The number of good or bad prognostic markers and the markers that are not influenced by a given treatment are shown. A score of +1 is given to a good prognostic marker whereas a score of -1 is given to a poor prognostic marker. The final score corresponds to the addition of good and poor prognostic markers. For 786-O cells, BVZ/INF and BVZ/INF/ERLO treatments gave positive scores (3 and 2 respectively) with the highest number of good prognostic indicators (8), whereas ERLO gave a negative score (-3) with the highest number of bad prognostic factors (-8). For A498 cells, BVZ/INF/ERLO treatment gave the worst score (-2) with the highest number of poor prognostic indicators (-7), whereas BVZ/INF and ERLO gave equivalent positive scores (1) with the highest number of good prognostic indicators for ERLO (7).