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A leader sequence should precede the variable region of germline-reverted antibody. This will insure that the mIgM ectodomain is assembled in the lumen of the ER. For CR6261, the leader sequence “mdwtwrflfvvaaatggvqs” (underlined) is used. Inputting the leader + variable region sequence into the SignalP 4.1 server (http://www.cbs.dtu.dk/services/SignalP/) confirms the presence and position of the introduced signal peptide cleavage site.
