Table 2.
Median (95% CI) |
Odds Ratio (95% CI) |
|||||
---|---|---|---|---|---|---|
Measurement | OATS-CTL (N=5) | OATS-INJ (N=5) | OATS-DLMS (N=6) | INJ vs. CTL | DLMS vs. CTL | DLMS vs. INJ |
OARSI (Cartilage, combined) | 12 (9 to 17) | 12 (7 to 15) | 8 (6 to 12) | 1.3 (0.6 to 2.7) | 2.2 (1.3 to 3.6)** | 1.6 (0.7 to 3.7) |
Structure | 2 (2 to 3) | 2 (1 to 3) | 2 (1 to 3) | 1.8 (0.9 to 3.5) | 1.5 (0.9 to 2.8) | 0.9 (0.4 to 2.0) |
Chondrocytes | 4 (2 to 4) | 4 (2 to 4) | 2 (1 to 3) | 1.1 (0.4 to 3.2) | 2.7 (1.5 to 5.1)** | 2.6 (0.9 to 7.4) |
Proteoglycans | 3 (2 to 4) | 3 (1 to 4) | 2 (1 to 2) | 1.0 (0.3 to 3.5) | 3.3 (1.4 to 7.5)** | 3.4 (1.0 to 11.4)* |
Collagen | 2 (1 to 3) | 2 (1 to 3) | 1 (1 to 2) | 1.1 (0.4 to 2.9) | 2.8 (1.5 to 5.1)** | 2.5 (0.9 to 6.8) |
Tidemark | 1 (0 to 2) | 0 (0 to 2) | 0 (0 to 2) | 1.8 (1.2 to 2.8)** | 1.7 (1.1 to 2.8)* | 1.0 (0.6 to 1.4) |
Bone | 1 (0 to 3) | 0 (0 to 3) | 3 (0 to 3) | 1.1 (0.6 to 2.4) | 0.7 (0.2 to 2.1) | 0.6 (0.2 to 1.8) |
p<0.05
p<0.01
p<0.001
OATS, osteochondral autograft transfer system; CTL, no dexamethasone supplementation group; DLMS, dexamethasone-loaded microsphere implant group; INJ, dexamethasone injection group