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. Author manuscript; available in PMC: 2021 Jan 15.
Published in final edited form as: Acta Biomater. 2019 Dec 2;102:326–340. doi: 10.1016/j.actbio.2019.11.052

Table 2.

OARSI cartilage scores and sub-scores

Median (95% CI)
Odds Ratio (95% CI)
Measurement OATS-CTL (N=5) OATS-INJ (N=5) OATS-DLMS (N=6) INJ vs. CTL DLMS vs. CTL DLMS vs. INJ
OARSI (Cartilage, combined) 12 (9 to 17) 12 (7 to 15) 8 (6 to 12) 1.3 (0.6 to 2.7) 2.2 (1.3 to 3.6)** 1.6 (0.7 to 3.7)
 Structure 2 (2 to 3) 2 (1 to 3) 2 (1 to 3) 1.8 (0.9 to 3.5) 1.5 (0.9 to 2.8) 0.9 (0.4 to 2.0)
 Chondrocytes 4 (2 to 4) 4 (2 to 4) 2 (1 to 3) 1.1 (0.4 to 3.2) 2.7 (1.5 to 5.1)** 2.6 (0.9 to 7.4)
 Proteoglycans 3 (2 to 4) 3 (1 to 4) 2 (1 to 2) 1.0 (0.3 to 3.5) 3.3 (1.4 to 7.5)** 3.4 (1.0 to 11.4)*
 Collagen 2 (1 to 3) 2 (1 to 3) 1 (1 to 2) 1.1 (0.4 to 2.9) 2.8 (1.5 to 5.1)** 2.5 (0.9 to 6.8)
 Tidemark 1 (0 to 2) 0 (0 to 2) 0 (0 to 2) 1.8 (1.2 to 2.8)** 1.7 (1.1 to 2.8)* 1.0 (0.6 to 1.4)
 Bone 1 (0 to 3) 0 (0 to 3) 3 (0 to 3) 1.1 (0.6 to 2.4) 0.7 (0.2 to 2.1) 0.6 (0.2 to 1.8)
*

p<0.05

**

p<0.01

***

p<0.001

OATS, osteochondral autograft transfer system; CTL, no dexamethasone supplementation group; DLMS, dexamethasone-loaded microsphere implant group; INJ, dexamethasone injection group