Table 1. Treatment Regimens for ANCA-associated Vasculitis, IgG Levels, and Number of Infections Prior to Commencement of SCIG.
ANCA: antineutrophil cytoplasmic antibody; AZA: azathioprine; CYC: cyclophosphamide; Ig: immunoglobulin; PLEX: plasmapheresis; RTX: rituximab; S: steroids; SCIG: subcutaneous immunoglobulin
Patient ID | Induction | Maintenance | RTX details | Duration of RTX cessation prior to SCIG (months) | Ig levels prior to SCIG (mg/dL) (Normal range 700 - 1,600 mg/dL) | Number of infections |
1 | S + CYC + PLEX + RTX | AZA | Induction 375 mg/m2 q week x 4 | 95 | 299 | 5 |
2 | S + RTX | RTX | Seven courses of induction 375 mg/m2 q week x 4 for initial disease and six relapses. Maintenance q six months | Ongoing RTX use | 484 | 2 |
3 | S + CYC | RTX | Induction 375 mg/m2 q week x 4; one dose of 500 mg for recurrence | 10 | 318 | 2 |
4 | S + CYC | RTX | Maintenance 1,000 mg q six months | Ongoing RTX use | 392 | 5 |