Table 2.
Genotype and Allele Frequency of AQP4 Between Drug Resistant and Responsive Patients
| SNP Locus | Genotype and Allele | AED Resistant N=222 | AED Responsive N=288 | OR (95% CI) | p |
|---|---|---|---|---|---|
| rs1058424 | TT | 67 (30.92%) | 107 (38.1%) | Reference | – |
| TA | 110 (50.7%) | 124 (44.1%) | 1.413 (0.947–2.109) | 0.090 | |
| AA | 40 (18.4%) | 50 (17.8%) | 1.245 (0.741–2.091) | 0.408 | |
| T | 244 (56.2%) | 338 (60.1%) | 1.175 (0.911–1.515) | 0.213 | |
| A | 190 (43.8%) | 224 (39.9%) | |||
| rs3763043 | GG | 72 (33.3%) | 114 (40.6%) | Reference | – |
| GA | 105 (48.6%) | 118 (42.0%) | 1.394 (0.938–2.072) | 0.101 | |
| AA | 39 (18.1%) | 49 (17.4%) | 1.222 (0.729–2.049) | 0.446 | |
| G | 249 (57.6%) | 346 (61.6%) | 1.177 (0.912–1.520) | 0.211 | |
| A | 183 (42.4%) | 216 (38.4%) | |||
| rs335931 | AA | 73 (33.5%) | 86 (30.7%) | Reference | – |
| CG | 112 (51.5%) | 140 (50.0%) | 0.960 (0.643–1.433) | 0.841 | |
| GG | 33 (15.1%) | 54 (19.3%) | 0.718 (0.421–1.227) | 0.226 | |
| A | 258 (59.2%) | 312 (55.7%) | 1.152 (0.894–1.484) | 0.273 | |
| G | 178 (40.8%) | 248 (44.3%) |
Notes: After multiple testing correction by using Bonferroni’s method, p<0.017 is accepted to be significant.