Table 3.
Genotype and Allele Frequency of KCNJ10 Between Drug Resistant and Responsive Patients
| SNP Locus | Genotype and Allele | AED Resistant N=222 | AED Responsive N=288 | OR (95% CI) | p |
|---|---|---|---|---|---|
| rs12122979 | GG | 105 (47.9%) | 148 (52.5%) | Reference | – |
| GA | 90 (41.4%) | 95 (33.7%) | 1.334 (0.910–1.957) | 0.140 | |
| AA | 24 (11.0%) | 39 (13.8%) | 0.832 (0.470–1.473) | 0.528 | |
| G | 300 (68.5%) | 391 (69.3%) | 1.039 (0.794–1.361) | 0.777 | |
| A | 138 (31.5%) | 173 (30.7%) | |||
| rs1186685 | TT | 126 (57.5%) | 176 61.5%) | Reference | – |
| TC | 77 (35.2%) | 88 (30.8%) | 1.125 (0.828–1.782) | 0.320 | |
| CC | 16 (7.3%) | 22 (7.7%) | 0.975 (0.480–1.908) | 0.900 | |
| T | 329 (75.1%) | 440 (76.9%) | 1.104 (0.825–1.478) | 0.504 | |
| C | 109 (24.9%) | 132 (23.1%) | |||
| rs6690889 | TT | 110 (50.2%) | 162 (57.7%) | Reference | – |
| TC | 90 (41.1%) | 92 (32.7%) | 1.428 (0.977–2.087) | 0.066 | |
| CC | 19 (8.7%) | 27 (9.6%) | 0.981 (0.515–1.868) | 0.954 | |
| T | 310 (70.8%) | 416 (74.0%) | 1.176 (0.899–1.555) | 0.254 | |
| C | 128 (29.2%) | 146 (26.0%) | |||
| rs2486253 | GG | 213 96.8%) | 272 (95.8%) | Reference | – |
| GT | 7 (3.2%) | 12 (4.2%) | 0.823 (0567–1.195) | 0.305 | |
| GG | 0 (0.0%) | 0 (0.0%) | – | – | |
| G | 433 (98.4%) | 556 (97.9%) | 1.335 (0.521–3.420) | 0.545 | |
| T | 7 (1.6%) | 12 (2.1%) | |||
| rs1186675 | CC | 197 (89.1%) | 258 (90.5%) | Reference | – |
| CT | 23 (10.4%) | 24 (9.1%) | 1.150 (0635–2.083) | 0.645 | |
| TT | 1 (0.5%) | 1 (0.4%) | 1.280 (0.079–20.676) | 0.862 | |
| C | 417 (94.3%) | 542 (95.1) | 0.861 (0.495–1.500) | 0.276 | |
| T | 25 (5.7%) | 28 (4.9%) | |||
| rs12402969 | TT | 194 (88.2%) | 242 (85.5%) | Reference | – |
| TC | 24 (10.9%) | 38 (13.4%) | 0.796 (0.460–1.475) | 0.413 | |
| CC | 2 (0.9%) | 3 (1.1%) | 0.835 (0.137–5.077) | 0.844 | |
| T | 412 (93.6%) | 522 (92.2%) | 0.806 (0.493–1.318) | 0.389 | |
| C | 28 (6.4%) | 44 (7.8%) | |||
| rs12729701 | AA | 127 (58.0%) | 163 (57.6) | Reference | – |
| AG | 80 (36.5%) | 106(37.5%) | 0.949(0.653–1.378) | 0.782 | |
| GG | 12 (5.5%) | 14 (4.9%) | 1.151 (0.513–2.584) | 0.734 | |
| A | 334 (76.3%) | 432 (76.3%) | 0.996 (0.743–1.336) | 0.980 | |
| G | 104 (23.7%) | 134 (23.7%) | |||
| rs1890532 | CC | 137 (62.3%) | 182 (64.5%) | Reference | – |
| CG | 65 (29.3%) | 86 (30.5%) | 1.007 (0.860–1.419) | 0.972 | |
| GG | 18 (8.2%) | 14 (5.0%) | 1.706 (0.819–3.555) | 0.154 | |
| C | 339 (77.0%) | 450 (79.8%) | 0.850 (0.628–1.150) | 0.293 | |
| G | 101 (23.0%) | 114 (20.2%) | |||
| rs3795339 | GG | 217 (98.6%) | 274 (96.5%) | Reference | – |
| GA | 3 (1.4%) | 10 (3.5%) | 0.388 (0.105–1.433) | 0.155 | |
| AA | 0 (0.0%) | 0 (0.0%) | – | – | |
| G | 437 (99.3%) | 558 (98.2%) | 2.611 (0.714–9.543) | 0.132 | |
| A | 3 (0.7%) | 10 (1.8%) |
Notes: After multiple testing correction by using Bonferroni’s method, p<0.006 is accepted to be significant.