Table 4.
Genotype and Allele Frequency of AQP4 Between All Idiopathic Focal Epilepsy Patients and Healthy Controls
| SNP Loci | Genotype and Allele | Patients N=393 | Healthy Controls N=206 | OR (95% CI) | p |
|---|---|---|---|---|---|
| rs1058424 | TT | 135 (35.0%) | 82 (40%) | Reference | – |
| TA | 185 (47.9%) | 88 (42.9%) | 1.362 (0.869–2.135) | 0.178 | |
| AA | 66 (17.1%) | 35 (17.1%) | 1.224 (0.680–2.204) | 0.500 | |
| T | 455 (58.9%) | 252 (61.5%) | 0.900 (0.704–1.150) | 0.399 | |
| A | 317 (41.4%) | 158 (38.5%) | |||
| rs3763043 | GG | 143 (37.1%) | 83 (40.5%) | Reference | – |
| GA | 178 (46.2%) | 87 (42.4%) | 1.338 (0.855–2.093) | 0.203 | |
| AA | 64 (16.6%) | 35 (17.1%) | 1.188 (0.660–2.139) | 0.565 | |
| G | 464 (60.2%) | 253 (61.7%) | 0.941 (0.736–1.203) | 0.628 | |
| A | 306 (39.8%) | 157 (38.3%) | |||
| rs335931 | AA | 122 (31.8%) | 68 (33.2%) | Reference | – |
| CG | 196 (51.0%) | 102 (49.8%) | 0.992 (0.627–1.569) | 0.972 | |
| GG | 66 (17.2%) | 35 (17.1%) | 1.110 (0.606–2.033) | 0.735 | |
| A | 440 (57.3%) | 238 (58.0%) | 0.969 (0.761–1.236) | 0.802 | |
| G | 328 (42.7%) | 172 (42.0%) |
Notes: After multiple testing correction by using Bonferroni’s method, p<0.017 is accepted to be significant.