Table 5.
Genotype and Allele Frequency of KCNJ10 Between All Idiopathic Focal Epilepsy Patients and Healthy Controls
| SNP Loci | Genotype and Allele | Patients N=393 | Healthy Controls N=206 | OR (95% CI) | p |
|---|---|---|---|---|---|
| rs12122979 | GG | 187 (48.4%) | 96 (46.8%) | Reference | – |
| GA | 150 (38.9%) | 84 (41.0%) | 0.824 (0.543–1.272) | 0.383 | |
| AA | 49 (12.7%) | 25 (12.2%) | 1.018 (0.519–2.000) | 0.958 | |
| G | 524 (67.8%) | 276 (67.3%) | 1.026 (0.794–1.325) | 0.845 | |
| A | 248 (32.2%) | 134 (32.7%) | |||
| rs1186685 | TT | 224 (57.6%) | 121 (58.7%) | Reference | – |
| TC | 138 (35.5%) | 70 (34.0%) | 1.040 (0.674–1.602) | 0.860 | |
| CC | 27 (6.9%) | 15 (7.3%) | 1.366 (0.562–3.075) | 0.512 | |
| T | 586 (75.3%) | 312 (75.7%) | 0.978 (0.741–1.292) | 0.877 | |
| C | 192 (24.7%) | 100 (24.3%) | |||
| rs6690889 | TT | 202 (52.5%) | 104 (50.7%) | Reference | – |
| TC | 148 (38.4%) | 87 (42.4%) | 0.794 (0.519–1.126) | 0.289 | |
| CC | 35 (9.1%) | 14 (6.8%) | 1.678 (0.718–3.924) | 0.232 | |
| T | 552 (71.7%) | 295 (72.0%) | 0.987 (0.756–1.289) | 0.924 | |
| C | 218 (28.3%) | 115 (28.0%) | |||
| rs2486253 | GG | 371 (95.6%) | 191 (93.2%) | Reference | – |
| GT | 17 (4.4%) | 14 (6.8%) | 0.610 (0.255–1.459) | 0.267 | |
| GG | 0 (0.0%) | 0 (0.0%) | – | – | |
| G | 759 (97.8%) | 396 (96.6%) | 1.578 (0.770–3.235) | 0.209 | |
| T | 17 (2.2%) | 14 (3.4%) | |||
| rs1186675 | CC | 349 (89.7%) | 187 (91.7%) | Reference | – |
| CT | 38 (9.8%) | 17 (8.3%) | 1.204 (0.584–2.841) | 0.615 | |
| TT | 2 (0.5%) | 0 (0.0%) | – | – | |
| C | 736 (94.6%) | 391 (95.8%) | 0.762 (0.428–1.356) | 0.354 | |
| T | 42 (5.4%) | 17 (4.2%) | |||
| rs12402969 | TT | 333 (85.8%) | 169 (86.8%) | Reference | – |
| TC | 51 (13.1%) | 33 (16.2%) | 0.615 (0.345–1.094) | 0.098 | |
| CC | 4 (1.0%) | 2 (1.0%) | 0.399 (0.053–2.156) | 0.252 | |
| T | 717 (92.4%) | 371 (90.9%) | 1.212 (0.789–1.863) | 0.380 | |
| C | 59 (7.6%) | 37 (9.1%) | |||
| rs12729701 | AA | 226 (58.4%) | 117 (57.1%) | Reference | – |
| AG | 144 (37.2%) | 74 (36.1%) | 1.120 (0.728–1.723) | 0.607 | |
| GG | 17 (4.4%) | 14 (1.8%) | 0.445 (0.187–1.063) | 0.068 | |
| A | 596 (77.0%) | 308 (75.1%) | 1.109 (0.838–1.467) | 0.469 | |
| G | 178 (23.0%) | 102 (24.9%) | |||
| rs1890532 | CC | 248 (64.2%) | 120 (58.5%) | Reference | – |
| CG | 111 (28.8%) | 70 (34.3%) | 0.636 (0.409–0.989) | 0.045 | |
| GG | 27 (7.0%) | 14 (6.9%) | 1.243 (0.541–2.853) | 0.608 | |
| C | 607 (78.6%) | 310 (76.0%) | 1.163 (0.875–1.546) | 0.299 | |
| G | 165 (21.4%) | 98 (34.0%) | |||
| rs3795339 | GG | 378 (97.4%) | 200 (97.1%) | Reference | – |
| GA | 10 (2.6%) | 5 (2.4%) | 0.626 (0.179–2.191) | 0.463 | |
| AA | 0 (0.0%) | 0 0.0%) | – | – | |
| G | 766 (98.8%) | 405 (98.3%) | 0.946 (0.321–2.785) | 0.919 | |
| A | 10 (1.2%) | 5 (0.7%) |
Notes: After multiple testing correction by using Bonferroni’s method, p<0.006 is accepted to be significant.