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. 2020 Jan 13;15(1):e0227047. doi: 10.1371/journal.pone.0227047

Fig 3. Treatment of THP-1 cells with LTA1 and dmLT induces comparable secretion of cytokines, including IL-1β, IFNγ, IL-4, and chemokines.

Fig 3

To evaluate changes to APCs, THP-1 cells were treated with media alone (untx) or with dmLT or LTA1 in μg dose/ml indicated. Cytokine analyses were performed with triplicate samples. (A) Heatmap of secreted cytokines after 24h culture detected by Bio-plex. (B) Graphs of selected cytokines from A. Significance tested by ANOVA with Bonferroni post-test for all groups compared to untx and 1 μg dmLT to 10 μg LTA1 (indicated in A as * for dmLT or # for LTA1 both 10 and 50 μg/ml significantly higher than untx, or in B *P ≤ 0.05 for all comparisons). Bars at mean+SEM.