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. 2019 Dec 23;15(12):e1006941. doi: 10.1371/journal.pcbi.1006941

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© 2019 Pharris et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — For all traces, models are stimulated by a 2sec pulse of Ca²⁺/CaM. (A) Active CaMKII subunits over time in our exclusive model. (B) Active CaMKII subunits over time in our non-exclusive model. (C) pThr-286 subunits over time in our exclusive model. (D) pThr-286 subunits over time in our non-exclusive model. (A-D) The parameter value for the rate of PP association (k_on^PP1) with CaMKII is either increased (purple traces) or decreased (orange traces) by one order of magnitude. (E) Extension of Fig 5 to include non-exclusive model results; the exclusive model results are also shown in Fig 5. At time t = 30sec (arrows), either a kinase inhibitor (light blue trace) or phosphatase inhibitor (light green trace) is introduced. No inhibitor is introduced in the control (grey trace). All traces are the average of N = 50 executions.