Fig 1. IL-23- and IL-23R-deficient mice are highly susceptible to systemic C. albicans infection.

Il23a^-/- and WT mice were infected with 2x10⁵ CFU C. albicans. Il23r^gfp/gfp mice and their respective controls were infected with 3x10⁵ CFU C. albicans. (A) Kidney fungal burden was determined at 48h post infection. Each dot represents one animal. The mean of each group is indicated. Graphs show pooled data from three independent experiments. (B) Transversal kidney sections were stained with PAS reagent 48h post infection. Representative images are shown. Scale bar = 2.5 mm. (C) Blood urea nitrogen (BUN) and creatinine levels were measured in the serum of the indicated groups 48h post infection. Bars are the mean with standard deviation (SD) of each group with n = 3. Data are representative of two independent experiments. (D) Fungal burden of each organ was determined at the indicated time points. Data shown are the mean of three animals. Statistics were calculated using unpaired Student’s t-Test (A, C) or two-way ANOVA (D) as appropriate. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.