Table 1. Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

ADL = activities of daily living

Adapted from the Cancer Therapy Evaluation Program, National Cancer Institute Common Terminology Criteria for Adverse Events v5.0 Program, Common Terminology Criteria for Adverse Events v5.0

https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf

Grade	1	2	3	4	5
Diarrhea/colitis	Increase of <4 stools per day over baseline (or mild increase in ostomy output compared with baseline) without colitis symptoms	Increase of 4-6 stools per day over baseline (or moderate increase in ostomy output compared with baseline) and/or colitis symptoms limiting instrumental ADLS	Baseline (or severe increase in ostomy output compared to baseline), colitis symptoms interfering with ADLs; incontinence; hospitalization indicated; limiting self-care ADL	Life-threatening consequences (e.g., perforation, hemodynamic instability); urgent intervention indicated	Death