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. Author manuscript; available in PMC: 2020 Jan 13.
Published in final edited form as: Bioorg Med Chem Lett. 2016 Jun 7;26(15):3603–3607. doi: 10.1016/j.bmcl.2016.06.010

Figure 2.

Figure 2.

Docking results of 27 and 1S in the hTRPV1 model. (A) 2-D illustration of the binding interactions between 27 (left) and 1S (right) with hTRPV1. Hydrogen bonding interactions are indicated by blue dashed line arrows and hydrophobic interactions are displayed with curved patches. (B) The Fast Connolly surface of hTRPV1 and the van der Waals surface of 27 (left) and 1S (right). The molecular surface of hTRPV1 is created by using MOLCAD and presented with the lipophilic potential property. For clarity, the surface of hTRPV1 is Z-clipped and that of the ligands are colored individually by magenta (27) or purple (1S).