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. Author manuscript; available in PMC: 2020 Jan 13.
Published in final edited form as: J Cell Physiol. 2012 May;227(5):1960–1971. doi: 10.1002/jcp.22924

Fig. 6.

Fig. 6.

Metastasis of Rspo2, Wnt1, and Rspo2/Wnt1 derived tumors to the lungs and/or spleen. A: Fragments of Rspo2, Wnt1, and Rspo2/Wnt1 tumors were implanted in the left and right#4 inguinal mammary gland of six female athymic nude mice. Tumors reaching size of 300–350 mg were removed in survival surgery and mice were subsequently monitored for evidence of metastases. The numbers in parenthesis reflect the number of mice with mammary tumors or lung/spleen metastasis. B: H&E staining of representative lung metastases. Rspo2 expressing cells gave rise to tumors with swirls of spindle-shaped neoplastic cells. Occasionally areas of densely packed more epithelial-like cells were found. Original magnification 100× upper row, 400× lower row.