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. Author manuscript; available in PMC: 2020 Jan 13.
Published in final edited form as: Eur J Med Chem. 2014 Nov 13;90:332–341. doi: 10.1016/j.ejmech.2014.11.025

Scheme 1.

Scheme 1.

Synthesis of cyclo-saturated alkyl acids. Reagents and conditions: (a) mCPBA, CH2Cl2, 0 °C; (b) SOCl2, CH3OH, r.t.; (c) Et2Zn,CH2I2,CH2Cl2, −5 °C; (d) 1 N LiOH, dioxane, 60 °C.